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Welcome to the MateraLab at UNC Chapel Hill!

At a Glance

  • Epigenetic gene regulation
  • Animal models of Spinal Muscular Atrophy
  • RNA processing and RNP assembly

The research in our laboratory interrogates fundamental molecular, cellular and developmental biological processes. In particular, we are interested in the roles played by small ribonucleoproteins (RNPs) in a genetic disease, called Spinal Muscular Atrophy.  We are also focused on the functions of histone post-translational modifications (PTMs) in the regulation of eukaryotic gene expression, important for understanding disease mechanisms in many different types of cancer.

A deeper, and somewhat more personal, perspective on the field of RNA biology and RNP research can be found here: Twenty Years of RNA.



Dept. of Biology.  Dept. of Genetics.  iBGS Program.  Lineberger Cancer Center.

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Drosophila and human body plan images courtesy of